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100			_aZhang, Donglu [Ed.] _97128
245			_aDrug Metabolism in Drug Design and Development : Basic Concepts and Practice _cEdited by Donglu Zhang, Mingshe Zhu, W. Griffith Humphreys
260			_aCanada _bJohn-Wiley _c2008
300			_axix, 609p.
500			_aThe essentials of drug metabolism vital to developing new therapeutic entities Information on the metabolism and disposition of candidate drugs is a critical part of all aspects of the drug discovery and development process. Drug metabolism, as practiced in the pharmaceutical industry today, is a complex, multidisciplinary field that requires knowledge of sophisticated analytical technologies and expertise in mechanistic and kinetic enzymology, organic reaction mechanism, pharmacokinetic analysis, animal physiology, basic chemical toxicology, preclinical pharmacology, and molecular biology. With chapters contributed by experts in their specific areas, this reference covers: Basic concepts of drug metabolism The role of drug metabolism in the pharmaceutical industry Analytical techniques in drug metabolism Common experimental approaches and protocols Drug Metabolism in Drug Design and Development emphasizes practical considerations such as the data needed, the experiments and analytical methods typically employed, and the interpretation and application of data. Chapters highlight facts, common protocols, detailed experimental designs, applications, and limitations of techniques. This is a comprehensive, hands-on reference for drug metabolism researchers as well as other professionals involved in pre-clinical drug discovery and development.
650			_aDrugs Metabolism _97129
650			_aDrugs Design _97130
650			_aDrug Evaluation methods _97131
650			_aDrug Design _95441
650			_aPharmaceutical Preparations _97132
650			_aDrug development _94359
700			_aZhu, Mingshe [Ed.] _97133
700			_aHumphreys, W. Griffith. [Ed.] _97134
856			_uhttp://www.loc.gov/catdir/toc/ecip0717/2007017661.html _yTable of contents only
856			_uhttp://www.loc.gov/catdir/enhancements/fy0739/2007017661-d.html _yPublisher description
856			_uhttp://www.loc.gov/catdir/enhancements/fy0805/2007017661-b.html _yContributor biographical information
942			_cBOOK _2ddc
999			_c4850 _d4850
856			_uhttp://14.139.59.218:80/cgi-bin/koha/opac-detail.pl?biblionumber=4850 _yhttp://14.139.59.218:80/cgi-bin/koha/opac-detail.pl?biblionumber=4850