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003			00IHBT
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020			_a3527305955
041			_hENG
080			_a
082			_a572.86
100			_aDemeunynck, M. [Ed.] _9597
245			_aDNA and RNA Binders: Small Molecular DNA and RNA Binders _cEdited by M. Demeunynck, C. Bailly, W.D. Wilson
246			_aDNA and RNA binders : from small molecules to drugs
260			_aVerlag _bWILEY-VCH _c2003
300			_a 2 v. (xxii, 732 p.)
500			_aThe development of molecules that selectively bind to nucleic acids has provided many details about DNA and RNA recognition. The range of such substances, such as metal complexes, peptides, oligonucleotides and a wide array of synthetic organic compounds, is as manifold as the functions of nucleic acids. Nucleic acid recognition sequences are often found in the major or minor groove of a double strand, while other typical interactions include intercalation between base pairs or the formation of triple or quadruple helices. One example of a binding mode that has recently been proposed is end stacking on such complex structures as the telomere tetraplex. In this comprehensive book, internationally recognized experts describe in detail the important aspects of nucleic acid binding, and in so doing present impressive approaches to drug design. Since typical substances may be created naturally or synthetically, emphasis is placed on natural products, chemical synthesis, the use of combinatorial libraries, and structural characterization. The whole is rounded off by contributions on molecular modeling, as well as investigations into the way in which any given drug interacts with its nucleic acid recognition site.
650			_aDNA-drug interactions _97067
650			_aMolecular biology. _93043
650			_aNucleic acids _97068
650			_aBinding sites (Biochemistry) _97069
700			_aBailly, Christian [Ed.] _97070
700			_aWilson, W. D. [Ed.] _97071
856			_uhttp://www.loc.gov/catdir/description/wiley041/2003279167.html _y Publisher description
856			_uhttp://www.loc.gov/catdir/toc/wiley041/2003279167.html _yTable of contents
942			_2ddc _cBOOK
999			_c3493 _d3493
856			_uhttp://14.139.59.218:80/cgi-bin/koha/opac-detail.pl?biblionumber=3493 _yhttp://14.139.59.218:80/cgi-bin/koha/opac-detail.pl?biblionumber=3493