Dealing with climate change is generally considered to be one of the greatest challenges for the coming decades. Changes in precipitation are likely to have a major impact on the hydrological cycle and subsequently on the environment and food production. However, until now clear guidance on how to respond to this challenge, particularly at the river basin level, has been lacking. This book has been developed from the ADAPT project, focusing on the development of regional adaptation strategies for water, food and the environment in river basins across the world. A generic methodology is presented and applied to seven case studies in contrasting geographical areas of the world: Mekong (SE Asia), Rhine (Western Europe), Sacramento (USA), Syr Darya (Central Asia), Volta (Ghana), Walawe (Sri Lanka) and Zayandeh (Iran).