| 000 -LEADER |
|---|
| fixed length control field |
02256nam a2200289Ia 4500 |
| 003 - CONTROL NUMBER IDENTIFIER |
|---|
| control field |
00IHBT |
| 005 - DATE AND TIME OF LATEST TRANSACTION |
|---|
| control field |
20140908102140.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
|---|
| fixed length control field |
130910s9999 xx 000 0 und d |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER |
|---|
| International Standard Book Number |
3527305955 |
| 041 ## - LANGUAGE CODE |
|---|
| Language code of original |
ENG |
| 082 ## - DEWEY DECIMAL CLASSIFICATION NUMBER |
|---|
| Classification number |
572.86 |
| 100 ## - MAIN ENTRY--PERSONAL NAME |
|---|
| Personal name |
Demeunynck, M. [Ed.] |
| 9 (RLIN) |
598 |
| 245 ## - TITLE STATEMENT |
|---|
| Title |
DNA and RNA Binders: Small Molecular DNA and RNA Binders |
| Statement of responsibility, etc. |
Edited by M. Demeunynck, C. Bailly, W.D. Wilson |
| 246 ## - VARYING FORM OF TITLE |
|---|
| Title proper/short title |
DNA and RNA binders : from small molecules to drugs |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. (IMPRINT) |
|---|
| Place of publication, distribution, etc. |
Verlag |
| Name of publisher, distributor, etc. |
WILEY-VCH |
| Date of publication, distribution, etc. |
2003 |
| 300 ## - PHYSICAL DESCRIPTION |
|---|
| Extent |
2 v. (xxii, 732 p.) |
| 500 ## - GENERAL NOTE |
|---|
| General note |
The development of molecules that selectively bind to nucleic acids has provided many details about DNA and RNA recognition. The range of such substances, such as metal complexes, peptides, oligonucleotides and a wide array of synthetic organic compounds, is as manifold as the functions of nucleic acids. Nucleic acid recognition sequences are often found in the major or minor groove of a double strand, while other typical interactions include intercalation between base pairs or the formation of triple or quadruple helices. One example of a binding mode that has recently been proposed is end stacking on such complex structures as the telomere tetraplex. In this comprehensive book, internationally recognized experts describe in detail the important aspects of nucleic acid binding, and in so doing present impressive approaches to drug design. Since typical substances may be created naturally or synthetically, emphasis is placed on natural products, chemical synthesis, the use of combinatorial libraries, and structural characterization. The whole is rounded off by contributions on molecular modeling, as well as investigations into the way in which any given drug interacts with its nucleic acid recognition site. |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name as entry element |
DNA-drug interactions |
| 9 (RLIN) |
7062 |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name as entry element |
Nucleic acids |
| 9 (RLIN) |
7063 |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name as entry element |
Binding sites (Biochemistry) |
| 9 (RLIN) |
7064 |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name as entry element |
Molecular biology. |
| 9 (RLIN) |
3043 |
| 700 ## - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Bailly, Christian [Ed.] |
| 9 (RLIN) |
7065 |
| 700 ## - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Wilson, W. D. [Ed.] |
| 9 (RLIN) |
7066 |
| 856 ## - ELECTRONIC LOCATION AND ACCESS |
|---|
| Uniform Resource Identifier |
http://www.loc.gov/catdir/description/wiley041/2003279167.html |
| Link text |
Publisher description |
| 856 ## - ELECTRONIC LOCATION AND ACCESS |
|---|
| Uniform Resource Identifier |
http://www.loc.gov/catdir/toc/wiley041/2003279167.html |
| Link text |
Table of contents |
| 856 ## - ELECTRONIC LOCATION AND ACCESS |
|---|
| Uniform Resource Identifier |
http://14.139.59.218:80/cgi-bin/koha/opac-detail.pl?biblionumber=3494 |
| Link text |
http://14.139.59.218:80/cgi-bin/koha/opac-detail.pl?biblionumber=3494 |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
|---|
| Source of classification or shelving scheme |
|
| Koha item type |
BOOK |
